Advances in Recombinant Human Growth Hormone Replacement Therapy in Adults
نویسنده
چکیده
Acquired growth hormone (GH) deficiency results from the destruction of normal pituitary and/or hypothalamic tissue, usually from a tumor or secondary to surgical and/or radiation therapy. Diagnostic criteria and clinical sequelae of GH deficiency, although well established in children, are currently areas of active investigation in the adult. It is now apparent that acquired GH deficiency is associated with significant changes in body composition, bone density, lipid metabolism, cardiovascular function and physical performance. In addition, new information is now available on the use of low doses of recombinant human growth hormone (rhGH) to reverse the sequelae of GH deficiency in adults.
منابع مشابه
Effects of Low-Dose Recombinant Human Growth Hormone on Bone Densities of Radius, Tibia and 4th Lumbar Vertebrae in Rabbits
Objective- To determine the effects of growth hormone (GH) therapy on bone density in controlled conditions in healthy adult rabbits. Design- Experimental in vivo study. Animal- 20 healthy, adult New Zealand White rabbits. Procedures- The rabbits were divided into 2 groups; receiving Human GH (0.006 mg/kg/d) and controls; receiving placebo for 3 months. The density of radius and tibia was m...
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